![]() Interestingly, of four successful transplants, three developed hematological malignancies with possible implications from their different genetic background as described herein. To further characterize the SCID pig and to maintain a research population, bone marrow transplantations (BMTs) were performed on select individuals. The naturally occurring Artemis SCID pig offers a large animal model more similar to human SCID patients and may offer a naturally occurring cancer model and provides a valuable platform for therapy development.Īfter the discovery of the Severe Combined Immunodeficiency (SCID) phenotype in pigs at Iowa State University (ISU), the phenotype’s genetic cause was determined to be two independent mutations segregating from independent founders. Human Artemis SCID patients have reported cases of lymphoma associated with a “leaky” Artemis phenotype. The other ART16/ART16 animal also presented with leukemia in addition to T cell lymphoma, while one of the ART12/ART16 compound heterozygote recipients presented with a nephroblastoma at a similar age. One of these ART16/ART16 recipients was a male who received a transplant from a female sibling the tumors in this recipient consist primarily of Y chromosome-positive cells. ![]() At approximately 11 months of age, both animals homozygous for the ART16 mutation were diagnosed with T cell lymphoma. Of nine original BMT transfer recipients, only four achieved successful engraftment. Bone marrow transplants (BMTs) were performed to create genetically SCID and phenotypically immunocompetent breeding animals to establish a SCID colony for further characterization and research utilization. 4Kansas State University, Manhattan, KS, United StatesĪfter the discovery of naturally occurring severe combined immunodeficiency (SCID) within a selection line of pigs at Iowa State University, we found two causative mutations in the Artemis gene: haplotype 12 (ART12) and haplotype 16 (ART16).3Gift of Life Michigan, Ann Arbor, MI, United States.2Department of Veterinary Pathology Science, Iowa State University, Ames, IA, United States.1Department of Animal Science, Iowa State University, Ames, IA, United States. ![]() Boettcher 1 Maureen Kerrigan 4 Raymond R. Ellinwood 1 Jesse Hostetter 2 Michael Yaeger 2 Chak-Sum Ho 3 Lynden Gault 3 Veronica Norlin 3 Elizabeth N.
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